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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '549bc600f0377541cfcbf1468fd6de6b9f5280c22e4891c5d6dcc0669250d12f' 
  AND token = 'td7/ppdmpXK9un8+iecp3D8uivLLeWiD1eE1XmraR9E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}