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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f88ef305a36f4eb60782877c03185a7bd4a525f11b7c77fe206486d9d9d80c1f' 
  AND token = '3X5Nf7Pvq01Wh51QMMsGXrOTWRniUoeF6RMVLlFLmdA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}