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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f65ddf8749d747119d6b6c55b7185a63b2dc33cdb963864c1a183a42d09ee810' 
  AND token = '227YKZuBV/uxW89i9OAIsTL9C4JBe5ec5rX480mFJCs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}