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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a8cbca1c374e69644d1aed5117e7af6938cf0db078f70df34b483a392b44659' 
  AND token = '2JUP3I2UoURiy+SENEkmVBC2zkR0NdbD3w3n0CH7Vpk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}