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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e50cda2d1248ba68f813c5b3ca1ce9ff20bdc331097263214cd71ac7864d6fc4' 
  AND token = 'uU1IFADyQ7IsFBgLxFIv4cBGNeuGBhOFkZ3tovb3SUM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}