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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b59da9e818af3f1635d31ac8691be4a2549741a071e186ae981fc1ed4d60359f' 
  AND token = 'vD0j9T3bTQOdPLZQzknclMAwMTHL7wi/zrKk4ZxN3tM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}