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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ee80b872b3cde626bf6b2b6fe1a929358db7a955f582db3324351c6994ff044' 
  AND token = 'htxy0CV8+SIRYuM/rKbyLIQvSp+Wn413aSlwTrpHOPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}