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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a8fbbf78ccde7d74225a17160d73eaa4932a65dc4429a4ab82b8e337a6d850' 
  AND token = 'ySF8zuH2KZGmhRGk7/2mtBtt4U/zHN41z3ok1mpIvok=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}