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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729de47ddd40e0bb010891da3e07f9952dc4a3d96ace817ddbf58bd56ef3e189' 
  AND token = 'iLs4h3aVFHzJhL32LE+08Raaf6f7TCpjbt5EeMk+oVU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}