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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '752279cfd7b5c408c8e550f55f2ba9818cffd65c31df87915ef75ae0be6d6345' 
  AND token = 'o1M+zRaTzOIHHCHEzDChVB1IDF1nZTT3n55VeXlEd7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}