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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a5dd8c40398074a05a4df219ad48fdfcbdb1c7637f60b5df35025a1bbc32f6f' 
  AND token = '16n2NXtmhPrHr6jTS4/TdK0o0ePQ5Zw9DydtHznBZOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}