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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf1309d67b3f44bdd9fe00effdab16ec99125890a5224dbceaad7ee69214348c' 
  AND token = 'zn8TZPsZTsizy4VEoS0x0KeUGJAgcf8bIVedn2vyvDc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}