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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dd35f253b8ea7f7cba441f706fdfab6b75a6fa8cd4dec18d54747ceff646d22' 
  AND token = 'U5QzerpJ+BnH2OdgEJlPfOAmF5/oCyDNLNN2qDf3LlQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}