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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c78f89260472977997d94d123d724b3e5eeff93bacbc45546d8876380516fc22' 
  AND token = 'eQlI9zC+yCX6RGxq9O2caakwCJ7F9DKTRW1nE3O/V4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}