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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0e69d9946be1777de4288aebb86aff6d29dcb38e8067bf446f82377296cac0c' 
  AND token = 'wqrfB5upyrw0U8FSzFlsxfV+mX/4dOmdRd9YusF2Yu8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}