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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8dd9f88a01a1b742b66b779eac549f5e1a208d308e3fa8d2f7f1348baa8400a6' 
  AND token = 'Kza+kjCIsQoBTikbYC3i+qZpJAbV9XT6A33ziRqpDy4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}