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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80d0f1c87abb2b6281a36e7a1e446919931471526250d432a3367c69a1ace6b6' 
  AND token = '2w3BGYO2PA5EOuJcAe4mK/gIGfSGwMa9dRuit0rPyuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}