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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a74a41a7354a87cf0f51ca97f2c559a63e5abca0bb12f9c045b0845e2bf83cba' 
  AND token = 'Uz7yw96/QIhYDVuoxeJrEOzqMQpAb+ii6uJ4fLD68k8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}