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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e22fe03bcb9e7f5a79d7b20c1c69ebbef723b5714bbcfd6ba1045e1eada1383' 
  AND token = 'NErqAUQijL8IMUoqQsDHnYp4s7agJY+JhP6GPNuXhSU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}