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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781dfec29d7911cdd0015529335b275f9695bc269d54bb497574509e1a009fca' 
  AND token = '8zOimReGEyEuAm3/LGuG25+UP+9s4SKJQYDtXRqWoGU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00078

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}