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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '780ba74fda59c69decd1070757c13f44f83d1dcca109049619014471ec642df9' 
  AND token = 'fDBviH8IR+wIWEOWAF8EgfS8KRLi0G7zZocrIjFOBvs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}