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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1622e9380a6cb705c98a76687bfdad53225b0d1cf75373d352a0975183a07186' 
  AND token = 'uGcJR082hTKYhtakjfurEC/FRsNfsDJA1CNAnIUcV0k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}