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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a43b1cdb70ad27833fdac79d4563a96f60f4dc6cf098db19d1c41950c741589' 
  AND token = '2gHePHofrKh+DLlbJj++PMbA7e39ZEDxQKxSEdrWcPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00081

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}