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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2495802578bc5910203e8b929483040c9eb45840cc8f3939d530c24717290934' 
  AND token = 'SolAaDz7OKpj4uq8vdF0jOEONSWmv1DcN/89o9VZIZU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}