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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '125a59901fbd9b4ff2bc33f3a26f833d150a1f554c03149e0f356339b339f8ea' 
  AND token = 'OuuaTRQ/0CE1jsJiiQ4NRRisFCcmJXTrnH40ltf2EHk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}