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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543e69888f06bcd533e51c81bed3d4a29c9211f2a12e5ba3946ca412824f41d2' 
  AND token = 'iZN3hl12OYjuS56axmf/R5ka0M8GZSSdo4gDLsGvt/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}