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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '533972e054b5e58e1062bd96f0c27b94fe4cb53ba7bfd990457e422d012ac5f3' 
  AND token = '6NYotOM5JnOCT6TNquKdfeS4wIxu2Ta1HOmW9Tgln4A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}