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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18458c404cc8bdda1ac0ebbb6c297fe085f5d2d3cafcdc55a29df4f1edc4b549' 
  AND token = '+ExXid20KA0HvvbIEw9MRbTLzZcFPAelVYZ7Z4YgetE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00079

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}