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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b718343c6fc5b98e67b5e0dd2638748971e2778327d9ad006a68b5376c1cb23' 
  AND token = '+DV72VHDcQmItOL++DIF1EHgGVcZMwkZAOdD31YV484=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}