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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2100cf0b8d8e99f450cbe71c0c967a16deecdb588d0483fa1c25637717003d01' 
  AND token = 'eDAsmymQEib+d+gCA/19DmWsjgP9BMpWuDSY5Rv0jy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00074

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}