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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dc8733e3cb9971965a2dc786ee92220d0677f3cba1386a25dd5b5d1a4b11dee' 
  AND token = 'k95cFYnXCZgwLMciEd+wtkW0xObrzwI3CxsGglZjCtE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}