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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd16520f5d64262275cce0906ceba1a6e1b54f2c8ac8835294628589571871707' 
  AND token = 'GQYVvwkEvE5VlYkjPHSX+/8d4PB8U6p0IxM1de3S1KM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}