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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f80ef39cce357097daec078938c2df8b37eb727429790ea156c8170c79c31c6' 
  AND token = 'iP0qNSC+cnOfb4yPGCLh2RBwFyThNquoQ3TKRJY+6ig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}