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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1058b21f70edefd0d870e32871519c1f37201161ee6b593146e2b4ce9f7b76c4' 
  AND token = 'LOZI/pkqe3L2+DpDXPbwh4Wob31d7OcVdfP38Fv4ohA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}