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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '09e5fa2468df89b4e7e6da32f7bc2b59525d85c6e5600b2b72b76f03560d1a44' 
  AND token = 'bxV0b3yLTN+BWvQ7hcJtx2M1esHlYJ848ybt0RJ5qQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}