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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6566d88321fdfff3879a15f3bd332f779c96bf2ca4f01e100fac9f3d22ae3666' 
  AND token = 't3eRV0Lh+Yq7Nkk4xnDNLGUVT8J+8jevDdkfMbYXoys=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}