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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48edd278792d59691033403109fc01d66abe6e057ad3fd977459436e5e2b09ff' 
  AND token = 'zKB0uLohCb/vWD7kM7QiMIuzj6/EafwplBoD2M6+dPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}