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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b8b1e625088868b1807cbbb91874f2c722bcd1db3663be8a38bbad2f9280a29' 
  AND token = 'gFM9Uf69tEh0UAfAmAFt3a+yMU/by4LqvSqCAWXDPOY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}