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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '468072223d624e6bd3552524de5e2f1b3da0b93b678cfa8c6e78e2fbecfba97f' 
  AND token = '6EF6kopo+kXciyL7UTr98oMezH00Rvo9GVXPKkQ7N/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}