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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2595d50efdb764ee1e0f151f665e3d163a158fb8e18e5dc6dfcee85a2f66dc62' 
  AND token = 'Mhu7APlHzWFnB2d7Wx/bHkhlrBbRLgOokH8kZVKhW/A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}